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Dynamic and regulated TAF gene expression during mouse embryonic germ cell development.
Gura MA, Mikedis MM, Seymour KA, de Rooij DG, Page DC, Freiman RN. Gura MA, et al. PLoS Genet. 2020 Jan 8;16(1):e1008515. doi: 10.1371/journal.pgen.1008515. eCollection 2020 Jan. PLoS Genet. 2020. PMID: 31914128 Free PMC article.
To begin understanding the transcriptional regulation underlying these complex processes, we examined the spatial and temporal expression of TAF4b, a variant TFIID subunit required for fertility, during embryonic germ cell development. By analyzing published datasets and u …
To begin understanding the transcriptional regulation underlying these complex processes, we examined the spatial and temporal expression of …
TAF4b Regulates Oocyte-Specific Genes Essential for Meiosis.
Grive KJ, Gustafson EA, Seymour KA, Baddoo M, Schorl C, Golnoski K, Rajkovic A, Brodsky AS, Freiman RN. Grive KJ, et al. PLoS Genet. 2016 Jun 24;12(6):e1006128. doi: 10.1371/journal.pgen.1006128. eCollection 2016 Jun. PLoS Genet. 2016. PMID: 27341508 Free PMC article.
To address the functional relevance of this analysis, we turned to the embryonic Taf4b-deficient mouse ovary where, for the first time, we demonstrate, severe deficits in prophase I progression as well as asynapsis in Taf4b-deficient oocytes. Accordingly, TAF4b …
To address the functional relevance of this analysis, we turned to the embryonic Taf4b-deficient mouse ovary where, for the first tim …
Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIID.
Falender AE, Freiman RN, Geles KG, Lo KC, Hwang K, Lamb DJ, Morris PL, Tjian R, Richards JS. Falender AE, et al. Genes Dev. 2005 Apr 1;19(7):794-803. doi: 10.1101/gad.1290105. Epub 2005 Mar 17. Genes Dev. 2005. PMID: 15774719 Free PMC article.
While young Taf4b-null males are initially fertile, Taf4b-null males become infertile by 3 mo of age and eventually exhibit seminiferous tubules devoid of germ cells. At birth, testes of Taf4b-null males appear histologically normal; however, at post-natal da …
While young Taf4b-null males are initially fertile, Taf4b-null males become infertile by 3 mo of age and eventually exhibit se …
Splicing factor SRSF1 is essential for homing of precursor spermatogonial stem cells in mice.
Sun L, Lv Z, Chen X, Ye R, Tian S, Wang C, Xie X, Yan L, Yao X, Shao Y, Cui S, Chen J, Liu J. Sun L, et al. Elife. 2024 Jan 25;12:RP89316. doi: 10.7554/eLife.89316. Elife. 2024. PMID: 38271475 Free PMC article.
Crosslinking immunoprecipitation and sequencing data revealed that spermatogonia-related genes (e.g. Plzf, Id4, Setdb1, Stra8, Tial1/Tiar, Bcas2, Ddx5, Srsf10, Uhrf1, and Bud31) were bound by SRSF1 in the mouse testes. ...The expression of spermatogonia-related genes (e.g. …
Crosslinking immunoprecipitation and sequencing data revealed that spermatogonia-related genes (e.g. Plzf, Id4, Setdb1, Stra8, Tial1/ …